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Updated: Aug 16, 2025
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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
Published on: October 13, 2016
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Sensory Involvement in Amyotrophic Lateral Sclerosis.
Miguel A Rubio1,2, Mireia Herrando-Grabulosa2, Xavier Navarro2
1Neuromuscular Unit, Department of Neurology, Hospital del Mar, 08003 Barcelona, Spain.
International Journal of Molecular Sciences
|December 23, 2022
Summary
Amyotrophic lateral sclerosis (ALS) involves more than motor neurons, with sensory and autonomic system dysfunction being increasingly recognized. This review details these non-motor aspects across multiple scientific perspectives.
Area of Science:
- Neuroscience
- Neurology
Background:
- Amyotrophic lateral sclerosis (ALS) is primarily known as a motor neuron disease.
- Emerging evidence highlights significant non-motor symptoms, including sensory and autonomic system involvement.
Purpose of the Study:
- To provide a comprehensive review of sensory and autonomic system involvement in ALS.
- To consolidate findings from clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular studies.
Main Methods:
- Literature review of studies on non-motor manifestations in ALS.
- Synthesis of data from diverse research methodologies.
Main Results:
- Sensory symptoms, though often clinically overshadowed, are pathologically relevant in ALS.
- Detailed description of sensory and autonomic system involvement across various scientific domains.
Conclusions:
- Non-motor symptoms are an integral component of ALS pathology.
- Further research into sensory and autonomic systems is crucial for a complete understanding of ALS.
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