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Vitamin D Metabolic Pathway Components in Orthopedic Patientes-Systematic Review.
Janusz Płomiński1,2, Roman Grzybowski2, Ewa Fiedorowicz3
1Clinical Department of Trauma-Orthopedic Surgery and Spine Surgery of the Provincial Specialist Hospital in Olsztyn, 10-561 Olsztyn, Poland.
International Journal of Molecular Sciences
|December 23, 2022
Summary
This review explores the vitamin D metabolic pathway
Area of Science:
- Orthopedics
- Biochemistry
- Metabolism
Background:
- Vitamin D is crucial for bodily homeostasis and skeletal health.
- Deficiencies are linked to various skeletal diseases.
- Its role in orthopedics is vital for bone growth and function.
Purpose of the Study:
- To review the vitamin D metabolic pathway components.
- To correlate these components with orthopedic conditions.
- To highlight knowledge gaps regarding the vitamin D pathway in orthopedics.
Main Methods:
- Literature search of PubMed (2010-2022).
- Keywords included vitamin D metabolites, binding proteins, enzymes (CYP24A1, CYP 27B1), receptors (VDR), and orthopedic conditions (ACL reconstruction, rotator cuff, arthroplasty).
- Analysis and discussion of recent original studies.
Main Results:
- Most studies focus on 25(OH)D, the standard diagnostic metabolite.
- The review analyzes key components of the vitamin D pathway.
- Identified numerous studies correlating vitamin D with orthopedic issues.
Conclusions:
- While 25(OH)D is widely studied, other vitamin D pathway elements warrant investigation.
- Further research is needed to understand the role of the full vitamin D pathway in orthopedic disorders.
- This review emphasizes the need for a comprehensive approach to vitamin D research in orthopedics.
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