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Updated: May 5, 2026

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Polyphosphazene-Based Biomaterials for Biomedical Applications.

Geun-Woo Jin1,2, N Sanoj Rejinold1, Jin-Ho Choy1,3,4,5

  • 1Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea.

International Journal of Molecular Sciences
|December 23, 2022
PubMed
Summary

Polyphosphazenes (PPZs) are versatile synthetic polymers with tunable properties, making them ideal for biomedical applications like drug delivery and tissue regeneration. This review highlights their potential as advanced biomaterials.

Keywords:
biocompatibilitybiodegradabilitydrug deliverypolyphosphazenes (PPZs)

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Area of Science:

  • Biomedical Science
  • Polymer Chemistry
  • Materials Science

Background:

  • Synthetic polymers are increasingly important in biomedical science.
  • Polyphosphazenes (PPZs) offer unique structural flexibility and biodegradability compared to other polymers.
  • Multi-functionalized PPZs can be tailored for diverse biomedical roles.

Purpose of the Study:

  • To review recent advancements in polyphosphazene-based biomaterials.
  • To highlight notable PPZ applications in medicine.
  • To discuss future perspectives for PPZ biomaterials.

Main Methods:

  • Literature review of existing studies on polyphosphazenes in biomedical applications.
  • Analysis of multi-functionalized PPZs in various forms (nanoparticles, hydrogels).
  • Synthesis and characterization of PPZ-based materials for specific applications.

Main Results:

  • Polyphosphazenes demonstrate significant potential in therapeutic molecule delivery (drugs, genes, proteins).
  • PPZs are effective in bioimaging, phototherapy, bone regeneration, and dental applications.
  • PPZ-based nanoparticles and hydrogels show promise for various medical devices and modifiers.

Conclusions:

  • Polyphosphazenes are highly promising biomaterials due to their adaptability and biodegradability.
  • Continued research into functionalized PPZs will expand their biomedical utility.
  • PPZ-based materials are poised for significant impact across multiple medical fields.