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Related Experiment Video

Updated: Aug 16, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Identification of Potential microRNA Panels for Male Non-Small Cell Lung Cancer Identification Using Microarray

Antonia Haranguș1,2, Raduly Lajos1, Livia Budisan1

  • 1Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.

Journal of Personalized Medicine
|December 23, 2022
PubMed
Summary

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SOPA and SIMPA: normalized single-sample integrated multiomics pathway analysis of tumor heterogeneity in solid cancers.

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ERS/ESGE/ESTS clinical practice guidelines on endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer.

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This study identifies key microRNA (miRNA) expression patterns in male non-small cell lung cancer (NSCLC) patients. These findings highlight potential diagnostic biomarkers and therapeutic targets for NSCLC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
  • MicroRNAs (miRNAs) are critical regulators implicated in NSCLC pathogenesis.
  • Understanding miRNA dysregulation in male NSCLC patients is crucial for advancing treatment strategies.

Purpose of the Study:

  • To investigate miRNA expression profiles in male NSCLC patients.
  • To identify specific miRNA signatures associated with NSCLC development.
  • To explore the functional roles and potential therapeutic implications of identified miRNAs.

Main Methods:

  • Integrated analysis of microarray data from male NSCLC patients and public TCGA datasets.
  • Quantitative reverse transcription PCR (qRT-PCR) for miRNA expression validation.
Keywords:
NSCLCmicroRNAmicroarray

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  • Construction of mRNA-miRNA regulatory networks to identify key molecular pathways.

    • Main Results:

    • Identified a common signature of eight overexpressed and nine underexpressed miRNAs in male NSCLC.
    • Validated specific miRNAs (miR-183-3p, miR-34c-5p) in tissue and plasma samples.
    • Revealed correlations between miRNA target genes, NSCLC signaling pathways, and overall survival.

    Conclusions:

    • Dysregulated miRNAs and their target genes are integral to NSCLC progression in males.
    • These findings offer potential biomarkers for NSCLC diagnosis and prognosis.
    • Identified miRNAs represent promising targets for novel NSCLC therapeutic interventions.