Related Experiment Video
Updated: Aug 16, 2025
08:59
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
10.7K
Peri-Neural Invasion Is an Important Prognostic Factor of T2N0 Oral Cancer
Chi-Sheng Cheng1, Chien-Chih Chen2,3, Yi-Chun Liu2,4
1Department of Oral and Maxillofacial Surgery, Taichung Veterans General Hospital, Taichung 407219, Taiwan, China.
Medicina (Kaunas, Lithuania)
|December 23, 2022
Summary
Perineural invasion (PNI) is a key independent prognostic factor for oral squamous cell carcinoma (OSCC) patients. Early-stage T2N0 OSCC patients with PNI have poorer survival, suggesting adjuvant therapy may improve outcomes.
Area of Science:
- Oncology
- Pathology
Background:
- Early-stage oral squamous cell carcinoma (T2N0 OSCC) can recur despite radical surgery.
- Prognostic indicators for T2N0 OSCC are not well-established in existing literature.
Purpose of the Study:
- To identify prognostic factors for T2N0 OSCC.
- To explore management strategies for improving survival in T2N0 OSCC patients.
Main Methods:
- Retrospective analysis of 166 T2N0 OSCC patients treated with radical surgery (2012-2017).
- Evaluation of clinical and pathological factors including perineural invasion (PNI), angiolymphatic invasion (ALI), and adjuvant therapy.
- Univariate and multivariate analyses, including Kaplan-Meier survival calculations for disease-specific survival (DSS) and disease-free survival (DFS).
Main Results:
- Perineural invasion (PNI) was identified as the sole independent prognostic factor for both DSS and DFS.
- Patients with PNI showed significantly lower 3-year DSS (57.0%) and DFS (54.6%) compared to those without PNI (90.8% DSS, 84.2% DFS).
- Adjuvant therapy (chemotherapy ± radiotherapy) appeared to prevent recurrence and mortality in the studied cohort.
Conclusions:
- Perineural invasion (PNI) is a significant independent prognostic factor in T2N0 oral squamous cell carcinoma.
- Adjuvant chemotherapy and radiotherapy may improve survival for T2N0 OSCC patients, warranting further investigation for optimal treatment regimens.
