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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Aug 16, 2025

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Membrane Applications in Autologous Cell Therapy.

Risto Martin1, Rui Lei1, Yida Zeng2

  • 1Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford OX3 7DQ, UK.

Membranes
|December 23, 2022
PubMed
Summary

Membranes offer a cost-effective solution for manufacturing cell therapies. This disruptive technology can significantly reduce the price of autologous cell therapies, making them more accessible.

Keywords:
autologous cell therapybioreactorcell culturehollow fibre membrane bioreactor (HFBR)

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Area of Science:

  • Biotechnology
  • Biomaterials Engineering
  • Regenerative Medicine

Background:

  • Autologous cell therapies are increasingly common but face high manufacturing costs.
  • Cost is a major barrier to the widespread clinical application of cell and stem cell therapies.

Purpose of the Study:

  • To explore the potential of membrane technology to reduce the cost of cell therapy manufacturing.
  • To highlight membranes as a disruptive technology for bioprocessing cellular products.

Main Methods:

  • Review of existing membrane applications in cell therapy manufacturing.
  • Discussion of membrane properties and module design for improved bioprocessing.

Main Results:

  • Membranes have been successfully used in CAR-T cell expansion, human stem cell culture, and extracellular vesicle (EV) production.
  • Hollow fiber membrane bioreactors are effective for EV production.

Conclusions:

  • Membrane technology can significantly reduce the cost of autologous cell therapies.
  • Development of novel membranes and modules is crucial for future advancements in cell therapy bioprocessing.