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Updated: Aug 16, 2025

Establishing a Device for Sleep Deprivation in Mice
Published on: September 22, 2023
Sleep Deprivation and Central Appetite Regulation
Shuailing Liu1, Xiya Wang1, Qian Zheng1
1Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, China.
Abstract:
Research shows that reduced sleep duration is related to an increased risk of obesity. The relationship between sleep deprivation and obesity, type 2 diabetes, and other chronic diseases may be related to the imbalance of appetite regulation. To comprehensively illustrate the specific relationship between sleep deprivation and appetite regulation, this review introduces the pathophysiology of sleep deprivation, the research cutting edge of animal models, and the central regulatory mechanism of appetite under sleep deprivation. This paper summarizes the changes in appetite-related hormones orexin, ghrelin, leptin, and insulin secretion caused by long-term sleep deprivation based on the epidemiology data and animal studies that have established sleep deprivation models. Moreover, this review analyzes the potential mechanism of associations between appetite regulation and sleep deprivation, providing more clues on further studies and new strategies to access obesity and metabolic disease.
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