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Published on: November 30, 2016
Nutritional Status and Selected Adipokines in Children with Irritable Bowel Syndrome
Wojciech Roczniak1, Agnieszka Szymlak2, Bogdan Mazur3
1Institute of Medicine, Jan Grodek State University in Sanok, ul. Mickiewicza 21, 38-500 Sanok, Poland.
Insights
Children with irritable bowel syndrome (IBS) show altered levels of specific adipokines, chemerin and omentin-1, which may serve as potential biomarkers. Nutritional status in these children is comparable to healthy peers.
Area of Science:
- Pediatric Gastroenterology
- Metabolic Research
- Nutritional Science
Background:
- Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder in children.
- Adipokines play a role in metabolic regulation and inflammation.
- Nutritional status and adipokine profiles in pediatric IBS are not fully understood.
Purpose of the Study:
- To assess nutritional status and serum adipokine concentrations in children with IBS compared to healthy controls.
- To investigate the relationship between adipokines, nutritional status, and metabolic parameters in pediatric IBS.
Main Methods:
- Study included 33 children with IBS (aged 5-17) and 30 healthy controls.
- Evaluated anthropometry, body composition (bioimpedance), and serum levels of leptin, adiponectin, chemerin, and omentin-1.
- Biochemical tests assessed metabolic parameters including triglycerides and HOMA-IR.
Main Results:
- Anthropometric measurements were similar between IBS patients and controls.
- IBS patients exhibited higher triglycerides, HOMA-IR, and chemerin levels.
- Lower HDL cholesterol and omentin-1 levels were observed in IBS patients; leptin and adiponectin showed no significant differences.
- Serum chemerin (≥ 232.8 ng/mL) and omentin-1 (≤ 279.4 ng/mL) demonstrated potential as biomarkers with good specificity.
Conclusions:
- Nutritional status is comparable between children with and without IBS.
- Serum concentrations of chemerin and omentin-1 differ significantly in pediatric IBS and may serve as potential biomarkers.
- Adipokine levels in IBS patients correlate with nutritional status and insulin resistance.
Background:
The aim of this study was to assess the nutritional status and serum concentrations of adipokines in children with irritable bowel syndrome (IBS) and healthy controls. We also sought to evaluate their relation to metabolic parameters.
Methods:
We studied 33 IBS patients (11 girls, 22 boys) aged 5-17 years and 30 healthy age-matched controls (11 girls, 19 boys). The analysis included anthropometric measurements, body composition parameter measurements using bioimpedance, and biochemical tests and measurements of serum concentrations of leptin, adiponectin, chemerin, and omentin-1.
Results:
The results of the anthropometric measurements were comparable between the patients and the controls. The patients had higher triglycerides, HOMA-IRs, and chemerin concentrations than the healthy subjects. The HDL cholesterol and omentin-1 levels were lower than in the controls. Leptin and adiponectin did not differ significantly between the groups. An analysis of the receiver operator curves (ROCs) showed that serum concentrations of chemerin ≥ 232.8 ng/mL had 30% sensitivity and 87% specificity when they were used to differentiate between children with IBS and healthy subjects. In the case of serum omentin-1 concentrations ≤ 279.4 ng/mL, the sensitivity and specificity were 60% and 80%, respectively.
Conclusions:
The nutritional status of children with IBS did not differ from that of the healthy controls. We found significant differences in serum chemerin and omentin-1 concentrations between IBS patients and healthy children. These adipokines could be used as IBS biomarkers as they demonstrate good specificity and moderate sensitivity. The serum concentrations of chemerin and omentin-1 in IBS patients were related to nutritional status and insulin resistance.
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