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Omics as a Tool to Help Determine the Effectiveness of Supplements
Anna Steg1, Maria Oczkowicz1, Grzegorz Smołucha1
1Department of Animal Molecular Biology, National Research Institute of Animal Production, ul. Krakowska 1, 32-083 Balice, Poland.
Nutrients
|December 23, 2022
Summary
Omics technologies like next-generation sequencing (NGS), liquid chromatography-mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR) help evaluate dietary supplements. These methods assess safety, efficacy, and personalized supplementation needs.
Area of Science:
- Biochemistry
- Genomics
- Metabolomics
Background:
- Dietary supplements are increasingly popular but understudied.
- High-throughput omics techniques offer novel ways to investigate their biological impact.
Purpose of the Study:
- To review the application of omics technologies in the study of dietary supplements.
- To highlight the utility of NGS, LC-MS, and NMR in assessing supplement efficacy and safety.
Main Methods:
- Review of existing literature on omics applications in dietary supplement research.
- Focus on Next-Generation Sequencing (NGS), Liquid Chromatography-Mass Spectrometry (LC-MS), and Nuclear Magnetic Resonance (NMR).
Main Results:
- NGS identifies relevant genetic pathways and patient polymorphisms for targeted supplementation.
- LC-MS quantifies supplement levels in serum and their metabolic effects.
- LC-MS and NMR determine supplement composition, metabolites, and toxicity, with NMR assessing factors influencing efficacy.
Conclusions:
- Omics techniques are valuable tools for understanding the impact of dietary supplements.
- These methods enable rigorous evaluation of supplement safety, efficacy, and personalized application.
