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Tibouchina granulosa Leaves Present Anti-Inflammatory Effect
Carolina Carvalho Guilhon1, Alan Silva Minho1, Marc Pouliot2
1Laboratório de Farmacologia da Dor e da Inflamação, Programa de Pesquisa em Descoberta de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Pharmaceuticals (Basel, Switzerland)
|December 23, 2022
Summary
The ethanol extract and ethyl acetate fraction from Tibouchina granulosa leaves show significant anti-inflammatory effects. These findings support the traditional use of this plant for reducing inflammation.
Area of Science:
- Phytochemistry
- Pharmacology
- Immunology
Background:
- Tibouchina granulosa is traditionally used for its medicinal properties.
- The anti-inflammatory potential of T. granulosa extracts requires scientific validation.
Purpose of the Study:
- To evaluate the anti-inflammatory capacity of T. granulosa ethanol extract (EE) and its ethyl acetate fraction (fEA).
- To identify chemical constituents in fEA and assess their contribution to anti-inflammatory activity.
Main Methods:
- In vivo anti-inflammatory models: formalin-induced licking and carrageenan-induced air pouch inflammation.
- In vitro assays: polymorphonuclear cell (PMN) activation, cytokine reduction (TNF-α, IL-1β, IFN-γ), nitric oxide (NO) production, and gene expression.
- Phytochemical analysis of fEA using HPLC-DAD.
Main Results:
- EE and fEA significantly reduced inflammatory responses in vivo and in vitro.
- Hispiduloside was identified as a major constituent (39.3%) in fEA.
- Both extracts markedly decreased pro-inflammatory cytokines, NO production, and PMN migration.
Conclusions:
- Ethanol extract and ethyl acetate fraction of T. granulosa leaves possess notable anti-inflammatory properties.
- These findings scientifically validate the traditional use of T. granulosa for inflammation management.
- The study contributes to the pharmacological and chemical understanding of T. granulosa.
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