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Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom Ganoderma australe
Lin Zhou1, He-Ping Chen1, Xinyang Li1,2
1School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
Abstract:
Two triterpenes, ganoaustralins A (1) and B (2), featuring unprecedented 6/6/6/5/6 scaffolds were isolated from the fruiting bodies of the mushroom Ganoderma australe. The structures were determined by extensive NMR and HRESIMS spectroscopic analysis. The absolute configuration of the C-25 in ganoaustralin A was assigned by the phenylglycine methyl ester (PGME) method. The relative and absolute configurations of the polycyclic backbones were determined by NMR and ECD calculations, respectively. The plausible biosynthetic pathways of ganoaustralins A and B were proposed. Ganoaustralin B showed weak inhibition against β-secretase 1.
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