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Exploiting Polyphenol-Mediated Redox Reorientation in Cancer Therapy
Lei Li1, Ping Jin2, Yueyue Guan3
1School of Basic Medical Sciences, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Pharmaceuticals (Basel, Switzerland)
|December 23, 2022
Summary
Polyphenols from Chinese herbal medicine show anticancer effects by regulating reactive oxygen species (ROS) and redox homeostasis. Further research into these compounds and novel delivery systems can enhance their therapeutic potential in oncology.
Area of Science:
- Oncology
- Pharmacology
- Redox Biology
Background:
- Polyphenols are key therapeutic components in Chinese herbal medicine (CHM).
- Their anticancer efficacy is linked to modulating redox homeostasis and reactive oxygen species (ROS) in cancer cells.
- Oxidative stress, driven by ROS, is crucial for tumor development and resistance.
Purpose of the Study:
- To review extensively studied polyphenols and their antitumor mechanisms.
- To discuss the role of ROS-mediated properties of polyphenols in cancer.
- To explore novel strategies for developing CHM-derived polyphenols as anticancer agents.
Main Methods:
- Literature review of polyphenols and their anticancer activities.
- Analysis of mechanisms involving redox homeostasis modulation.
- Discussion of novel technologies for polyphenol development.
Main Results:
- Polyphenols exhibit significant anticancer effects in vitro and in vivo.
- Modulation of redox homeostasis and ROS levels is a key mechanism.
- Various polyphenol categories, including flavonoids and phenolic acids, are effective.
Conclusions:
- Investigating ROS-mediated anticancer properties of polyphenols is vital for drug discovery.
- Novel delivery systems, chemical modification, and combination therapies can enhance CHM-derived polyphenols' anticancer potential.
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