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Achievements in Mesoporous Bioactive Glasses for Biomedical Applications
María Vallet-Regí1,2, Montserrat Colilla1,2, Isabel Izquierdo-Barba1,2
1Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, 28040 Madrid, Spain.
Pharmaceutics
|December 23, 2022
Summary
Mesoporous bioactive glasses (MBGs) show great promise for bone regeneration due to their unique properties and drug delivery capabilities. Research is advancing MBGs for multifunctional bone tissue engineering and therapeutic applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Materials Chemistry
Background:
- Mesoporous bioactive glasses (MBGs) are advanced bioceramics with unique chemical, structural, and textural properties.
- Their easily functionalizable surface enhances bioactivity and enables local drug delivery for bone regeneration.
- MBGs are increasingly recognized for their potential in treating bone pathologies and as multitherapy systems.
Purpose of the Study:
- To review recent developments in mesoporous bioactive glasses (MBGs) for biomedical applications, particularly in bone tissue engineering.
- To outline the role of MBGs in designing 3D scaffolds with specific properties for bone regeneration.
- To discuss the fabrication of multifunctional MBGs through ion incorporation and surface modification for enhanced therapeutic outcomes.
Main Methods:
- Overview of MBG design and fabrication for 3D scaffolds in bone tissue engineering.
- Exploration of methods for developing multifunctional MBGs, including ion doping and surface functionalization (e.g., with zwitterionic moieties).
- Review of literature on MBGs as delivery systems for various therapeutic agents (osteogenic, angiogenic, antibacterial, anti-inflammatory, antitumor).
Main Results:
- MBGs are effective in creating scaffolds that meet the demanding requirements of bone tissue engineering.
- Functionalization strategies, such as incorporating therapeutic ions and zwitterionic coatings, enhance MBG capabilities.
- MBGs demonstrate significant potential as carriers for diverse therapeutic agents, addressing multiple aspects of bone healing and disease.
Conclusions:
- Mesoporous bioactive glasses are versatile materials for bone tissue regeneration and local drug delivery.
- Ongoing research focuses on optimizing MBG properties and surface functionalization for advanced therapeutic applications.
- Further development is needed to overcome challenges and facilitate the clinical translation of MBG-based therapies.
