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Regulated mRNA Transport

Regulated mRNA Transport

In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...

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Updated: Aug 16, 2025

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

Cell-Derived Vesicles for mRNA Delivery.

Zhenghua Li¹, Zhen Liu¹, Jiacai Wu^1,2

¹Department of Infectious Disease, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology & The Second Clinical Medical College of Jinan University, Shenzhen 518020, China.

|December 23, 2022

Summary

This summary is machine-generated.

Cell-derived vesicles offer a promising natural solution for messenger RNA (mRNA) delivery, overcoming toxicity and targeting challenges for advanced therapeutics.

Keywords:

cell-derived vesicles exosome extracellular vesicles mRNA delivery microvesicles

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Published on: November 13, 2014

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Last Updated: Aug 16, 2025

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

Published on: June 10, 2022

In Vitro Synthesis of Modified mRNA for Induction of Protein Expression in Human Cells

In Vitro Synthesis of Modified mRNA for Induction of Protein Expression in Human Cells

Published on: November 13, 2014

Area of Science:

Biotechnology
Nanomedicine
Drug Delivery Systems

Background:

Clinical translation of messenger RNA (mRNA) therapeutics necessitates safe and effective delivery systems.
Existing mRNA delivery systems face challenges including dose-limiting toxicity and targeting extrahepatic tissues.

Purpose of the Study:

To review recent advances in naturally occurring cell-derived vesicles for mRNA delivery.
To discuss the biomedical applications and future perspectives of cell-derived vesicles in clinical translation.

Main Methods:

Literature review of naturally occurring cell-derived vesicles as mRNA delivery platforms.
Analysis of their properties, including biocompatibility, cell-specific tropism, and barrier crossing capabilities.

Main Results:

Cell-derived vesicles are endogenous membranous particles suitable for mRNA loading.
These vesicles show potential due to their natural origin, biocompatibility, and targeting abilities.

Conclusions:

Cell-derived vesicles represent a promising platform for overcoming current limitations in mRNA delivery.
Further research into their clinical translation is warranted for advancing mRNA-based therapeutics.