Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design, synthesis and biological evaluation of a 4,6-di(aziridin-1-yl)-1,3,5-triazine-benzimidazole hybrid as a potential dual-targeting anticancer agent.

Future medicinal chemistry·2026
Same author

Synthesis and Antitumor Potency of 2<i>E</i>,21<i>E</i>-bis-(2-Pyridinylidene)-hollongdione in NCI-60 Panel and Zebrafish Model.

International journal of molecular sciences·2026
Same author

Folate-Functionalized Albumin-Containing Systems: Non-Covalent vs. Covalent Binding of Folic Acid.

Pharmaceutics·2026
Same author

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration.

Small science·2025
Same author

Folate-Modified Albumin-Functionalized Iron Oxide Nanoparticles for Theranostics: Engineering and In Vitro PDT Treatment of Breast Cancer Cell Lines.

Pharmaceutics·2025
Same author

New Anticancer Agents: Design, Synthesis and Evaluation.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Aug 16, 2025

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

Published on: November 20, 2018

6.6K

Albumin-Functionalized Iron Oxide Nanoparticles for Theranostics: Engineering and Long-Term In Situ Imaging.

Anna V Bychkova1, Marina N Yakunina2, Mariia V Lopukhova1

  • 1Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, 4, Kosygina Str., Moscow 119334, Russia.

Pharmaceutics
|December 23, 2022
PubMed
Summary

New magnetic nanosystems (MNSs) using iron oxide nanoparticles coated with human serum albumin show promise for cancer theranostics. These MNSs demonstrated safe, long-term tumor presence and potential as computed tomography contrast agents.

Keywords:
computed tomography (CT)free radical approach (FRA)human serum albumin (HSA)iron oxide magnetic nanoparticles with peroxidase-like activitytheranostics

More Related Videos

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
08:26

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

12.2K
Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

10.4K

Related Experiment Videos

Last Updated: Aug 16, 2025

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

Published on: November 20, 2018

6.6K
Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
08:26

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

12.2K
Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

10.4K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Magnetic nanosystems (MNSs) are crucial for theranostics.
  • Iron oxide nanoparticles (IONPs) coated with human serum albumin (HSA) are key components.
  • Peroxidase-like activity of IONPs is a focus for biomedical applications.

Purpose of the Study:

  • To engineer and characterize MNSs composed of HSA-coated IONPs.
  • To evaluate the in vivo behavior and safety of these MNSs as computed tomography contrast agents.
  • To explore the theranostic potential of MNSs in oncology.

Main Methods:

  • HSA coating on IONPs via adsorption and free radical modification.
  • Hydroxyl radical generation confirmed by spin trap technique.
  • Dynamic light scattering (DLS) and electron magnetic resonance (EMR) for coating stability.
  • In vivo studies in tumor-bearing rats with intraarterial administration.
  • Colorimetric assay with o-phenylenediamine (OPD) for peroxidase-like activity.

Main Results:

  • Synthesized MNSs (~35 nm) exhibited stable HSA coatings.
  • Long-term (14 days) MNSs presence in tumor vascular beds was confirmed in vivo.
  • No significant adverse reactions or systemic toxicity were observed.
  • Demonstrated peroxidase-like activity using OPD substrate.

Conclusions:

  • Engineered MNSs are stable, biocompatible, and suitable for in vivo applications.
  • MNSs show potential as computed tomography contrast agents for tumor imaging.
  • The synthesized MNSs hold promise for future theranostic applications in oncology.