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Bioprinted Membranes for Corneal Tissue Engineering: A Review
Amin Orash Mahmoud Salehi1, Saeed Heidari-Keshel2, Seyed Ali Poursamar3
1Department of Chemistry and Nanotechnology, School of Engineering and Science, Tecnologico de Monterrey, Monterrey 64849, NL, Mexico.
Pharmaceutics
|December 23, 2022
Summary
Corneal tissue engineering (CTE) offers a promising solution to donor cornea shortages and transplant rejection. Three-dimensional bioprinting techniques are explored for creating scaffolds that mimic corneal structure for enhanced regeneration.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Regenerative Medicine
Background:
- Corneal transplantation faces challenges including donor scarcity and immune rejection.
- Existing solutions for corneal disorders are limited by tissue availability and transplant risks.
- Corneal tissue engineering (CTE) is emerging as a viable alternative for corneal regeneration.
Purpose of the Study:
- To review the anatomy and function of corneal layers.
- To discuss the potential of 3D bioprinting for corneal regeneration.
- To explore engineered scaffolds mimicking corneal properties.
Main Methods:
- Review of current literature on corneal anatomy, function, and transplantation.
- Analysis of various substrate development approaches for corneal regeneration.
- Focus on 3D bioprinting techniques for creating tissue-engineered corneal scaffolds.
Main Results:
- 3D bioprinting offers precise spatial control for fabricating complex corneal structures.
- Engineered scaffolds aim to match the optical and mechanical properties of native cornea.
- Bioprinted scaffolds show potential for simulating corneal structure with multiple cell types.
Conclusions:
- Corneal tissue engineering, particularly 3D bioprinting, presents a significant advancement in addressing corneal disease.
- Bioprinted scaffolds hold promise for overcoming donor tissue limitations and improving regenerative outcomes.
- Further research into optimizing scaffold properties is crucial for clinical translation.
