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MUPS Tableting-Comparison between Crospovidone and Microcrystalline Cellulose Core Pellets
Daniel Robin Thio1, Paul Wan Sia Heng1, Lai Wah Chan1
1GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore.
Pharmaceutics
|December 23, 2022
Summary
Microcrystalline cellulose (MCC) pellets showed better resistance to coat damage during multi-unit pellet system (MUPS) tablet manufacturing than crospovidone (XPVP) pellets. MCC pellets maintained sustained drug release more effectively under compaction pressure.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Drug Delivery Systems
Background:
- Multi-unit pellet system (MUPS) tablets are designed for controlled drug release.
- Ethylcellulose (EC) coating on pellets provides sustained drug release but is susceptible to damage during tableting.
- Pellet core deformability influences coat integrity and drug release performance.
Purpose of the Study:
- To compare the mechanical strength and coat integrity of drug-loaded pellets using microcrystalline cellulose (MCC) versus crospovidone (XPVP) as spheronization aids.
- To evaluate the impact of compaction pressure and pellet volume fraction on EC-coated pellet coat damage during MUPS tableting.
- To assess the effect of pellet core material on sustained drug release function after compaction.
Main Methods:
- Drug-loaded pellets were prepared using extrusion-spheronization with MCC or XPVP.
- Pellets were coated with ethylcellulose (EC) for sustained release.
- Pellets were compacted into MUPS tablets at varying pressures and volume fractions.
- Drug release profiles were analyzed to quantify EC coat damage.
Main Results:
- Pellets containing XPVP exhibited less favorable physical properties and greater EC coat damage compared to MCC pellets.
- MCC pellets demonstrated superior mechanical strength, resulting in significantly less coat damage.
- Despite some coat damage, MUPS tablets of acceptable quality could be manufactured using XPVP pellets.
Conclusions:
- Microcrystalline cellulose (MCC) is a preferable spheronization aid for producing MUPS tablets with robust EC-coated pellets that resist tableting-induced coat damage.
- Crospovidone (XPVP) can be used, but requires careful optimization of tableting parameters to mitigate coat damage and maintain drug release performance.
- Pellet core deformability is a critical factor influencing the success of MUPS tablet manufacturing and the integrity of sustained-release coatings.
Keywords:
MUPS tabletcompaction energycrospovidoneethylcellulosemicrocrystalline cellulosepellet coat damagepellet corespheronization aidMore Related Videos
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