Related Experiment Video
Updated: Aug 16, 2025

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
Published on: September 5, 2019
Variational inference of fractional Brownian motion with linear computational complexity
Hippolyte Verdier1,2, François Laurent1, Alhassan Cassé2
1Decision and Bayesian Computation, USR 3756 (C3BI/DBC) and Neuroscience Department CNRS UMR 3751, Institut Pasteur, Université de Paris, CNRS, 75015 Paris, France.
Abstract:
We introduce a simulation-based, amortized Bayesian inference scheme to infer the parameters of random walks. Our approach learns the posterior distribution of the walks' parameters with a likelihood-free method. In the first step a graph neural network is trained on simulated data to learn optimized low-dimensional summary statistics of the random walk. In the second step an invertible neural network generates the posterior distribution of the parameters from the learned summary statistics using variational inference. We apply our method to infer the parameters of the fractional Brownian motion model from single trajectories. The computational complexity of the amortized inference procedure scales linearly with trajectory length, and its precision scales similarly to the Cramér-Rao bound over a wide range of lengths. The approach is robust to positional noise, and generalizes to trajectories longer than those seen during training. Finally, we adapt this scheme to show that a finite decorrelation time in the environment can furthermore be inferred from individual trajectories.
Related Concept Videos
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Linear Approximation in Time Domain
For a simple pendulum with a mass evenly distributed along its length and the center of mass located at half the pendulum's length,...
Linear Approximation in Frequency Domain
In contrast, nonlinear systems do not inherently possess these properties. However, for small deviations around an operating point, a nonlinear system can often be approximated as linear....
Bernoulli's Equation: Problem Solving
The first step is to compute the cross-sectional areas of the pipe and the Venturi throat to analyze the pressure difference indicated by the pressure gauge. Next, the continuity...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Curvilinear Motion: Rectangular Components
As the car advances, its position evolves over time. Quantifying the car's velocity involves computing the...

