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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
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Emerging Role of Interferon-Induced Noncoding RNA in Innate Antiviral Immunity
Jie Min1,2, Wenjun Liu1,2,3, Jing Li1,2
1CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Viruses
|December 23, 2022
Summary
Interferon-induced noncoding RNAs (ncRNAs) are key players in the host
Area of Science:
- Immunology
- Genetics
- Molecular Biology
Background:
- Higher eukaryotes possess thousands of unique noncoding RNAs (ncRNAs).
- Virus infection triggers host interferon (IFN) production, activating hundreds of interferon-stimulated genes (ISGs) for antiviral defense.
- IFN-induced ncRNAs are emerging as critical regulators in the innate immune response against viruses.
Purpose of the Study:
- To review the complex regulatory roles of interferon-induced noncoding RNAs in antiviral innate immunity.
- To enhance understanding of ncRNA functions in host defense mechanisms.
- To provide a reference for basic research in antiviral innate immunity.
Main Methods:
- Literature review of studies on noncoding RNAs and antiviral immunity.
- Analysis of RNA-sequencing data identifying IFN-induced ncRNAs.
- Synthesis of current knowledge on ncRNA-mediated regulation of immune responses.
Main Results:
- IFN-induced ncRNAs modulate the expression of viral proteins, IFNs, and ISGs.
- These ncRNAs also regulate host genes involved in viral replication, cytokine/chemokine production, and signaling pathways.
- A complex regulatory network orchestrated by ncRNAs is crucial for effective antiviral innate immunity.
Conclusions:
- Interferon-induced noncoding RNAs play a multifaceted role in antiviral innate immunity.
- Understanding these ncRNAs is vital for advancing research in host defense mechanisms.
- This review consolidates current knowledge, offering insights into ncRNA-mediated immune regulation.
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