Related Experiment Video
Updated: Aug 16, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
Systemic inflammatory markers in elderly patients undergoing transcatheter aortic valve replacement
Haitham Abu Khadija1, Mechael Welt1, Gera Gendelman1
1Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with the Hebrew University, Jerusalem, Israel.
Transcatheter aortic valve replacement (TAVR) causes an inflammatory response, with higher white blood cell counts and neutrophil-lymphocyte ratios in older patients linked to adverse outcomes. However, survival rates remain similar across age groups post-TAVR.
Area of Science:
- Cardiology
- Geriatrics
- Inflammation Research
Background:
- Transcatheter aortic valve replacement (TAVR) induces an early inflammatory response.
- The impact of age on post-TAVR inflammatory markers and clinical outcomes requires further investigation, especially in octogenarians.
Purpose of the Study:
- To compare inflammatory marker changes after TAVR between octogenarians and younger patients.
- To investigate the association between post-TAVR inflammatory markers and adverse clinical outcomes in elderly patients.
Main Methods:
- Retrospective analysis of 507 patients undergoing transfemoral TAVR for severe symptomatic aortic stenosis.
- Evaluation of total white blood cell (WBC) counts and differential subpopulations at admission and post-procedure.
Main Results:
- Patients aged ≥ 80 showed significant kinetic changes in WBC and subpopulations post-TAVR (P < 0.0001).
- Higher WBC and neutrophil counts correlated with increased 30-day mortality and major vascular complications.
- Elevated neutrophil counts and neutrophil-lymphocyte ratios were associated with 30-day arrhythmia.
Conclusions:
- This study is the first to describe age-related differences in the inflammatory response post-TAVR.
- Post-TAVR inflammatory markers are associated with clinical outcomes, but survival rates are comparable between elderly and younger patients.
More Related Videos
Related Concept Videos
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Acute Coronary Syndrome III: Diagnostic Studies
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Aortic Regurgitation III: Medical Management

