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Introduction to the themed collection on fragment-based drug discovery
David C Rees1, Anna K H Hirsch2, Daniel A Erlanson3
1Astex 436 Cambridge Science Park Cambridge CB4 0QA UK David.Rees@astx.com.
RSC Medicinal Chemistry
|December 23, 2022
Summary
This collection explores fragment-based drug discovery, a key method for developing new medicines. It highlights advancements and strategies in identifying novel drug candidates.
Area of Science:
- Medicinal Chemistry
- Drug Discovery
- Chemical Biology
Background:
- Fragment-based drug discovery (FBDD) is a powerful approach for identifying novel drug leads.
- This method utilizes small molecular fragments to build potent and selective drug candidates.
- FBDD offers advantages over traditional high-throughput screening in certain contexts.
Discussion:
- This themed collection showcases cutting-edge research in fragment-based drug discovery.
- It covers diverse applications and innovative techniques within the field.
- The articles provide insights into the challenges and successes of FBDD.
Key Insights:
- The collection emphasizes the growing importance of FBDD in modern drug development pipelines.
- It highlights successful case studies and emerging trends in fragment screening and optimization.
- Expert contributions offer valuable perspectives on the future of FBDD.
Outlook:
- Future directions in FBDD include integrating computational methods and novel biophysical techniques.
- The field is poised for continued growth, contributing to the development of therapeutics for unmet medical needs.
- This collection serves as a valuable resource for researchers and practitioners in drug discovery.