Monotherapy of Biofiller for Atrophic Acne Scars: A Prospective Nonrandomized Study

Area of Science:

• Dermatology
• Regenerative Medicine
• Aesthetic Procedures

Background:

• Atrophic acne scarring presents a significant therapeutic challenge due to its persistent nature.
• Platelet-poor plasma (PPP) gel, derived from autologous blood, is utilized as a biofiller for skin rejuvenation.
• The study investigates a novel application of PPP gel in treating acne-related scarring.

Purpose of the Study:

• To evaluate the efficacy of platelet-poor plasma (PPP) gel injections in improving the appearance of atrophic acne scars.
• To assess the safety profile and potential side effects associated with PPP gel biofiller treatments.
• To determine the clinical outcomes using standardized scar assessment scales.

Main Methods:

• A study involving 30 patients with atrophic acne scars was conducted.
• Platelet-poor plasma (PPP) was extracted from patient blood, converted into a gel (biofiller), and injected monthly for six months.
• Scar severity was assessed using the Goodman and Baron Scar (GBS) scale, Physician Global Assessment, and Visual Analogue Scale (VAS).

Main Results:

• Significant improvement in atrophic acne scars was observed, with the mean GBS score decreasing from 28 to 8.2.
• Statistical analysis (ANOVA and paired t-test) confirmed a highly significant reduction in scar severity (P < 0.0001).
• Transient, localized side effects were noted, indicating a favorable safety profile.

Conclusions:

• Platelet-poor plasma (PPP) gel biofiller demonstrates significant efficacy in treating atrophic acne scars.
• The procedure is simple, minimally invasive, and cost-effective.
• Autologous PPP gel offers a safe alternative with no risk of immunogenic reactions.