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Staphylococcus aureus endocarditis: Identifying prognostic factors using a method derived from morbidity and
Benjamin Lefèvre1,2, Antoine Legoff1, Mathilde Boutrou3
1Université de Lorraine, CHRU-Nancy, Service des Maladies Infectieuses et Tropicales, Nancy, France.
Frontiers in Medicine
|December 23, 2022
Summary
Lethality in Staphylococcus aureus infective endocarditis (SaIE) may be predicted by new factors. Prior NSAID use, unperformed valve surgery, and decreasing vegetation size on antibiotics were identified as significant prognostic factors in SaIE patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Clinical Medicine
Background:
- Staphylococcus aureus infective endocarditis (SaIE) has a high mortality rate.
- Unidentified prognostic factors may contribute to SaIE lethality.
- Identifying new prognostic factors is crucial for improving patient outcomes.
Purpose of the Study:
- To identify novel prognostic factors for Staphylococcus aureus infective endocarditis (SaIE).
- To assess the prognostic value of these newly identified factors in SaIE patients.
Main Methods:
- A two-step approach was employed, starting with qualitative review of medical records from 30 SaIE patients (15 deceased, 15 survivors).
- Quantitative data for candidate factors were collected from 134 SaIE patients.
- Multivariate Cox models were used to determine the prognostic value of identified factors.
Main Results:
- Three factors demonstrated significant prognostic value in multivariate analysis.
- Prior use of non-steroidal anti-inflammatory drugs (NSAIDs) was associated with increased mortality (aHR 3.60).
- Non-performance of indicated valve surgery (aHR 1.85) and decreasing vegetation size on antibiotic treatment (aHR 0.34) were also significant.
Conclusions:
- Three potential prognostic factors for SaIE have been identified.
- These findings may aid in refining the management strategies for SaIE patients.
- External validation of these factors is recommended for clinical application.
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