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Atherogenic index of plasma and coronary artery disease: A systematic review

Juan R Ulloque-Badaracco1,2, Enrique A Hernandez-Bustamante3,4, Esteban A Alarcon-Braga1,2

  • 1Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Perú.

Open Medicine (Warsaw, Poland)
|December 23, 2022
PubMed

Insights

The atherogenic index of plasma (AIP) is linked to increased coronary artery disease (CAD) risk. Higher AIP levels significantly elevate the odds of developing CAD, underscoring its role as a potential biomarker.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Epidemiology

Background:

  • The atherogenic index of plasma (AIP) is increasingly recognized for its association with cardiovascular risk.
  • Existing studies suggest a link between AIP and coronary artery disease (CAD) across various populations.
  • A comprehensive synthesis of this evidence is needed to clarify the association.

Purpose of the Study:

  • To systematically review and meta-analyze the existing literature on the association between AIP and CAD.
  • To quantify the risk of CAD associated with elevated AIP levels.
  • To explore potential sources of heterogeneity in the observed associations.

Main Methods:

  • A systematic literature search was conducted across PubMed, Scopus, Web of Science, and Ovid-Medline, supplemented by handsearching preprint repositories.
  • Included studies reported on the association between AIP and CAD, with effect measurements expressed as odds ratios (OR) and 95% confidence intervals (CI).
  • A random-effects model was employed for quantitative synthesis of data from 14 articles involving 40,902 participants.

Main Results:

  • The meta-analysis of 14 studies revealed a significant association between increased AIP and higher odds of developing CAD (OR 2.11; 95% CI 1.65-2.69).
  • Subgroup analyses indicated this association holds for both Chinese (OR 1.89; 95% CI 1.40-2.56) and non-Chinese populations (OR 2.51; 95% CI 1.42-4.42).
  • Sensitivity analyses confirmed the robustness of the association, with high heterogeneity (I² = 98%) consistently observed.

Conclusions:

  • Elevated atherogenic index of plasma (AIP) is significantly associated with an increased risk of coronary artery disease (CAD).
  • AIP serves as a valuable biomarker for predicting CAD risk.
  • Further research may explore the clinical utility of AIP in risk stratification and management strategies.

Keywords:
atherosclerosiscoronary diseasedyslipidemiasheart diseaseslipids

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