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Ampelopsin targets in cellular processes of cancer: Recent trends and advances

Hardeep Singh Tuli1, Katrin Sak2, Vivek Kumar Garg3

  • 1Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana 133207, India.

Toxicology Reports
|December 23, 2022
PubMed

Insights

Ampelopsin, a plant-derived compound, shows promising anti-cancer effects by targeting key cellular processes. This review details ampelopsin

Area of Science:

  • Phytochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Cancer poses a global health challenge with limited therapeutic options and significant side effects.
  • Plant-based metabolites are being explored for chemo-preventive potential.
  • Ampelopsin (dihydromyricetin) exhibits promising anti-cancer properties.

Purpose of the Study:

  • To review the anti-tumor cellular targets of ampelopsin.
  • To elucidate the mechanistic insights of ampelopsin's phytochemical actions.
  • To provide a comprehensive understanding for researchers in the field.

Main Methods:

  • Literature review of studies on ampelopsin's anti-cancer mechanisms.
  • Analysis of molecular targets modulated by ampelopsin.
  • Synthesis of current research on ampelopsin's effects on apoptosis, angiogenesis, metastasis, and inflammation.

Main Results:

  • Ampelopsin modulates key molecules involved in cancer progression.
  • It enhances apoptosis-inducing proteins.
  • It inhibits tumor growth by regulating angiogenic and metastatic proteins and suppressing inflammatory markers.

Conclusions:

  • Ampelopsin demonstrates significant potential as a chemo-preventive agent.
  • Its multi-targeted action provides a mechanistic basis for its anti-cancer effects.
  • Further research into ampelopsin is warranted to develop novel cancer therapeutics.
Keywords:
AmpelopsinAngiogenesis inhibitionAnti-inflammationAnti-proliferationApoptoticCell cycle arrest

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