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Expression, Detergent Solubilization, and Purification of a Membrane Transporter, the MexB Multidrug Resistance Protein
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Molecular mechanisms of multidrug resistance in clinically relevant enteropathogenic bacteria (Review)

Julia Alexsandra González-Villarreal1, Katia Jamileth González-Lozano2, Elva Teresa Aréchiga-Carvajal2

  • 1Faculty of Biological Sciences, Autonomous University of Coahuila, Torreón, Coahuila 27275, Mexico.

Experimental and Therapeutic Medicine
|December 23, 2022
PubMed

Insights

Multidrug resistant (MDR) bacteria pose a significant clinical challenge. This review explores their genomic resistance mechanisms and treatment strategies for developing new antimicrobials.

Area of Science:

  • Microbiology
  • Genomics
  • Pharmacology

Background:

  • Multidrug resistant (MDR) enteropathogenic bacteria present a growing clinical challenge.
  • Their acquired tolerance to antibiotics leads to severe illnesses and significant healthcare costs.
  • Understanding MDR mechanisms is crucial for effective treatment and control.

Purpose of the Study:

  • To review the genomic mechanisms of antibiotic resistance in bacteria, including naturally acquired resistance.
  • To discuss current pharmacological and alternative treatments for MDR bacterial infections.
  • To provide information for developing novel antimicrobials and adjuvant therapies.

Main Methods:

  • Genomic analysis of antibiotic resistance mechanisms.
  • Literature review of pharmacological and alternative treatments.
  • Synthesis of information for antimicrobial development.

Main Results:

  • Detailed description of genomic basis for MDR in enteropathogenic bacteria.
  • Overview of existing treatment options for MDR infections.
  • Identification of targets for novel antimicrobial development.

Conclusions:

  • Genomic insights are vital for combating MDR bacteria.
  • A combination of established and novel treatments is necessary.
  • Further research into antimicrobial and adjuvant molecule development is essential.
Keywords:
enteropathogenic bacteriagastrointestinal diseasehorizontal gene transfermultidrug resistancetherapeutic research

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