A simple method for the preparation of CeO₂with high antioxidant activity and wide application range

Cerium oxide (CeO₂) is a well-known antioxidant with the ability to scavenge reactive oxygen species due to its unique electronic structure and chemical properties. Although many methods to enhance the antioxidant activity of CeO₂have been reported, its antioxidant activity is still not high enough, and some enhancement effects are limited by the material concentration. There are also some CeO₂obtained with high antioxidant activity at high concentrations, which is not conducive to the application of biomedicine. Therefore, it is urgent to obtain CeO₂material with low cell cytotoxicity, high antioxidant activity and wide application range. In this work, rod-like metal organic framework derived CeO₂(CeO₂-MOF) was prepared by a simple method. Compared with the CeO₂nanorods prepared by hydrothermal method, it shows better antioxidant activity compared with the CeO₂nanorods prepared by hydrothermal method. Moreover, the advantage of CeO₂-MOF's antioxidant activity is not affected by the hydroxyl radical and material concentrations The reason why CeO₂-MOF has higher antioxidant activity should be attributed to its higher Ce³⁺content and larger specific surface area. In addition, CeO₂-MOF also exhibits low cytotoxicity to HeLa cells and PC12 cellsin vitro. The strategy of using MOF as a structural and compositional material to create CeO₂provides a new method to explore highly efficient and biocompatible CeO₂for practical applications.