Related Experiment Video
Updated: Aug 16, 2025
Author Spotlight: Advancements in Retroperitoneal Approach for Necrotizing Pancreatitis
Published on: March 15, 2024
Infections in Acute Pancreatitis: Organisms, Resistance-Patterns and Effect on Mortality
Fang Li1,2, Feng Zhang2, Xueqin Wan1
1Department of Intensive Care Unit, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Background:
Acute pancreatitis (AP) is a common gastrointestinal disease in which infection is a serious complication. Understanding its bacterial spectrum and antibiotic resistance is of great significance for treatment.
Objective:
This retrospective study analyzed the Medical Information Mart for Intensive Care database with the aim of identifying the distribution characteristics of pathogenic bacteria in AP patients.
Methods:
First, 2089 AP patients were classified and analyzed statistically according to culture results. Second, the bacterial profile, antibiotic resistance, and antibiotic-use data of positive culture group were analyzed. Third, logistic regression analysis was used to identify the rick factors of culture results, and culture results correlations with mortality.
Results:
This study included 1486 patients in negative culture group, 603 patients in positive cultures. Enterococcus spp. (71%), Enterococcus faecium (61%), and Staphylococcus aureus coagulase-positive (54%) exhibited the highest proportions of drug resistance. Logistic regression revealed five factors related to positive culture (the number of antibiotics, length of stay in hospital, length of stay in intensive care unit, mechanical ventilation, and parenteral nutrition) and four factors related to distribution of multidrug-resistant bacterial infection (age, hemoglobin, length of stay in hospital, and duration on antibiotics).
Conclusions:
This study found that enteric bacteria were the most common source of infection (26.7%). Carbapenems, penicillins containing enzyme inhibitors, fifth-generation cephalosporins, oxazolidinones, and some of the aminoglycoside antibiotics had high sensitivity, which can guide the use of clinical empiric antibiotics. Positive culture was an independent risk factor for in-hospital all-cause mortality of AP patients.
Insights
Infections in acute pancreatitis (AP) patients are often caused by enteric bacteria. Identifying bacterial resistance patterns is crucial, as positive cultures independently increase mortality risk.
Area of Science:
- Infectious Diseases
- Gastroenterology
- Critical Care Medicine
Background:
- Acute pancreatitis (AP) is a prevalent gastrointestinal condition.
- Infection represents a significant complication in AP patients.
- Understanding bacterial spectrum and antibiotic resistance is vital for effective treatment.
Purpose of the Study:
- To identify the distribution characteristics of pathogenic bacteria in AP patients.
- To analyze bacterial profiles and antibiotic resistance patterns.
- To determine risk factors for positive cultures and their correlation with mortality.
Main Methods:
- Retrospective analysis of the Medical Information Mart for Intensive Care (MIMIC) database.
- Statistical classification and analysis of 2089 AP patients based on culture results.
- Logistic regression analysis to identify risk factors and mortality correlations.
Main Results:
- Enterococcus spp., Enterococcus faecium, and Staphylococcus aureus showed high drug resistance.
- Factors associated with positive cultures included antibiotic number, hospital and ICU stay, ventilation, and parenteral nutrition.
- Age, hemoglobin, hospital stay, and antibiotic duration were linked to multidrug-resistant infections.
Conclusions:
- Enteric bacteria are the most common source of infection in AP.
- Specific antibiotics demonstrated high sensitivity, guiding empiric therapy.
- Positive culture results are an independent risk factor for in-hospital mortality in AP patients.
Related Concept Videos
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
01:25Urinary Tract Infection II: Pathophysiology
01:30Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
01:27Acute Pyelonephritis I: Introduction