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Updated: Aug 16, 2025

A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors

A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors

Published on: October 30, 2016

Monkeypox: potential vaccine development strategies.

José Manuel Lozano¹, Sylviane Muller²

¹Universidad Nacional de Colombia-Sede Bogotá, Departamento de Farmacia, Mimetismo molecular de los Agentes infecciosos, Bogotá, DC, Colombia.

Trends in Pharmacological Sciences

|December 23, 2022

Summary

This summary is machine-generated.

Monkeypox virus (MPXV) research is crucial for developing effective treatments and vaccines. This review covers MPXV re-emergence, current vaccines, and future vaccine development strategies.

Keywords:

emerging infection orthopoxvirus peptides smallpox synthetic vaccines

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Last Updated: Aug 16, 2025

A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors

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Published on: October 30, 2016

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Published on: May 15, 2014

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Published on: May 24, 2020

Area of Science:

Virology
Immunology
Epidemiology

Background:

A global monkeypox outbreak has raised public health concerns.
Understanding the monkeypox virus (MPXV) is essential for developing countermeasures.
Previous research on MPXV provides a foundation for current investigations.

Purpose of the Study:

To review the current understanding of monkeypox virus (MPXV).
To discuss the re-emergence of MPXV globally.
To summarize existing vaccines and explore novel vaccine development avenues.

Main Methods:

Literature review of monkeypox virus (MPXV) research.
Analysis of epidemiological data on MPXV outbreaks.
Evaluation of current and proposed vaccine strategies.

Main Results:

Monkeypox virus (MPXV) re-emergence necessitates urgent scientific attention.
Existing vaccines show promise but may require further development.
Several promising avenues exist for novel MPXV vaccine design.

Conclusions:

Continued basic research on MPXV is vital for effective public health interventions.
A combination of antivirals and vaccines will be key to controlling MPXV spread.
Further investment in MPXV vaccine research is warranted.