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Local memory allocation recruits memory ensembles across brain regions.

Ayal Lavi¹, Megha Sehgal¹, Andre F de Sousa¹

¹Departments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.

|December 23, 2022

Summary

This study reveals how brain regions coordinate to form memories. Aversive memory formation in one brain area triggers a retrograde signal, recruiting neurons in upstream regions to establish a cohesive memory trace.

Keywords:

CREB auditory fear conditioning conditioned taste aversion cross-regional recruitment memory allocation memory coordination memory ensemble rabies retrograde mechanism

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Area of Science:

Neuroscience
Memory Research
Systems Neuroscience

Background:

Memory storage involves neuronal ensembles across brain regions.
Coordination mechanisms of these ensembles during learning are poorly understood.

Purpose of the Study:

To investigate how neuronal ensembles are coordinated across brain regions during memory formation.
To elucidate the role of retrograde signaling in establishing memory traces.

Main Methods:

Combined CREB-mediated memory allocation with transsynaptic retrograde tracing in mice.
Analyzed behavioral and brain region specificity of memory allocation.
Utilized statistical modeling.

Main Results:

Memory allocation in downstream neurons directly influences upstream neuronal recruitment.
This cross-regional recruitment is specific to behavior and brain region.
Evidence suggests a retrograde mechanism initiated by downstream memory neurons.

Conclusions:

Memory trace establishment involves both anterograde and retrograde information flow.
Retrograde mechanisms are crucial for coordinating brain-wide memory ensembles during learning.