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Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Allergic Reactions02:06

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Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Cross-reactivity00:42

Cross-reactivity

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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Related Experiment Video

Updated: Aug 16, 2025

Basophil Activation Test for Allergy Diagnosis
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Drug Allergy Practice Parameter Updates to Incorporate Into Your Clinical Practice.

Aleena Banerji1, Roland Solensky2, Elizabeth J Phillips3

  • 1Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

The Journal of Allergy and Clinical Immunology. in Practice
|December 23, 2022
PubMed
Summary
This summary is machine-generated.

This updated practice parameter provides guidance on diagnosing and managing drug hypersensitivity, focusing on antibiotic allergies and aspirin/NSAID reactions. It emphasizes delabeling penicillin allergies and using drug challenges effectively.

Area of Science:

  • Clinical Immunology
  • Pharmacology
  • Allergy and Immunology

Background:

  • The previous drug allergy practice parameter was last updated in 2010.
Keywords:
AntibioticAspirinChallengeChemotherapyDesensitizationDrug allergyHypersensitivitySkin testingTolerance

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  • Significant advancements in research and evidence-based data necessitate an update.
  • Key areas requiring updated guidance include antibiotic, NSAID, and chemotherapy drug allergies.