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Claude Syndrome in Childhood Associated with Probable Neuro-Behcet Disease

Pinar Yavuz1, Ismail Solmaz1, Ummusen Akca Kaya2

  • 1Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Neuropediatrics
|December 23, 2022
PubMed

Insights

This study reports two childhood cases of Claude syndrome, a rare midbrain stroke affecting the third cranial nerve and causing hemiataxia. Investigations suggested probable neuro-Behcet disease as a potential cause in these pediatric stroke patients.

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Neuroscience

Background:

  • Claude syndrome is a rare midbrain stroke syndrome.
  • It is characterized by ipsilateral third cranial nerve palsy and contralateral hemiataxia.
  • Pediatric cases are exceptionally uncommon.

Purpose of the Study:

  • To report two pediatric cases of Claude syndrome.
  • To highlight the clinical and imaging findings.
  • To discuss potential etiologies, including neuro-Behcet disease.

Main Methods:

  • Case presentation of two children diagnosed with Claude syndrome.
  • Clinical evaluation including neurological examination.
  • Brain magnetic resonance imaging (MRI) for diagnosis.
  • Etiological investigation for underlying causes.

Main Results:

  • Two children, aged 9 and 15, presented with Claude syndrome.
  • Clinical presentation correlated with MRI findings.
  • Etiological workup was inconclusive but suggested probable neuro-Behcet disease.

Conclusions:

  • Claude syndrome is a rare but important diagnosis in pediatric stroke.
  • Timely diagnosis and management are crucial.
  • Further investigation into potential causes like neuro-Behcet disease is warranted in similar pediatric cases.

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