Challenging neurovascular coupling through complex and variable duration cognitive paradigms: A subcomponent analysis

A similar pattern of cerebral blood velocity (CBv) response has been observed for neurovascular coupling (NVC) assessment with cognitive tasks of varying complexity and duration. This lack of specificity could result from parallel changes in arterial blood pressure (BP) and PaCO₂, which could confound the estimates of NVC integrity. Healthy participants (n = 16) underwent recordings at rest (5 min sitting) and during randomized paradigms of different complexity (naming words (NW) beginning with P-, R-, V- words and serial subtractions (SS) of 100-2, 100-7, 1000-17, with durations of 5, 30 and 60 s). Bilateral CBv (middle cerebral arteries, transcranial Doppler), end-tidal CO₂ (EtCO₂, capnography), blood pressure (BP, Finapres) and heart rate (HR, ECG) were recorded continuously. The bilateral CBv response to all paradigms was classified under objective criteria to select only responders, then the repeated data were averaged between visits. Bilateral CBv change to tasks was decomposed into the relative contributions (subcomponents) of arterial BP (V_BP; neurogenic), critical closing pressure (V_CrCP; metabolic) and resistance area product (V_RAP; myogenic). A temporal effect was demonstrated in bilateral V_BP and V_RAP during all tasks (p<0.002), increased V_BP early (between 0 and 10 s) and followed by decreases of V_RAP late (25-35 s) in the response. V_CrCP varied by complexity and duration (p<0.046). The main contributions to CBv responses to cognitive tasks of different complexity and duration were V_BP and V_RAP, whilst a smaller contribution from V_CrCP would suggest sensitivity to metabolic demands. Further studies are needed to assess the influence of different paradigms, ageing and cerebrovascular conditions.