Related Experiment Video
Updated: Aug 16, 2025

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
Familial Monkeypox Virus Infection Involving 2 Young Children
Abstract:
We report intrafamilial transmission of monkeypox virus to all members of a family (father, mother, and 2 children). Case reports in young children have been extremely rare during the 2022 mpox outbreak. Their clinical signs were mild, and clinical diagnosis would be difficult without knowledge of the father's monkeypox virus infection.
Insights
Intrafamilial transmission of the monkeypox virus (mpox) occurred in a family of four. Mild clinical signs in children made diagnosis challenging without knowing the father
Area of Science:
- Virology
- Public Health
- Pediatrics
Background:
- The 2022 mpox outbreak saw rare cases in young children.
- Intrafamilial spread of monkeypox virus is a documented phenomenon.
Purpose of the Study:
- To document intrafamilial transmission of monkeypox virus (mpox) within a family unit.
- To highlight the clinical presentation of mpox in children during the 2022 outbreak.
Main Methods:
- Case report detailing transmission within a family.
- Clinical observation of mpox symptoms in affected individuals.
Main Results:
- All four family members (father, mother, two children) were infected.
- Children presented with mild clinical signs of mpox.
- Diagnosis in children was complicated by the mildness of symptoms and lack of initial suspicion.
Conclusions:
- Intrafamilial transmission of mpox can affect all household members, including children.
- Mild clinical manifestations in children may hinder early diagnosis.
- Awareness of potential household exposure is crucial for identifying mpox in pediatric cases.

