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Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

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Related Experiment Video

Updated: Aug 16, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Developing a National Infrastructure for Proton Beam Therapy Trials

R Rieu¹, A Crellin², D Thomson³

¹The Institute of Cancer Research, London, UK; Head and Neck Unit, The Royal Marsden, London, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))

|December 23, 2022

Summary

No abstract available in PubMed .

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