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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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The multifaceted role of MUC1 in tumor therapy resistance

Weiqiu Jin1,2, Mengwei Zhang2,3, Changzi Dong4

  • 1Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200025, China.

Clinical and Experimental Medicine
|December 23, 2022
PubMed

Insights

Mucin1 (MUC1) overexpression drives tumor therapeutic resistance by impacting gene expression, genome stability, and tumor microenvironment. This review details MUC1

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Tumor therapeutic resistance is a major cause of cancer recurrence and poor prognosis.
  • Mucin1 (MUC1) is overexpressed in many human tumors and linked to treatment resistance.

Purpose of the Study:

  • To review the diverse roles of MUC1 in tumor therapy resistance.
  • To explore both common and therapy-specific resistance mechanisms involving MUC1.

Main Methods:

  • Literature review of MUC1's function in cancer therapy resistance.
  • Analysis of MUC1's involvement in chemotherapy, radiotherapy, and biotherapy resistance.
  • Summary of MUC1-related pan-cancer principles and clinical trials.

Main Results:

  • MUC1 contributes to resistance through gene expression interference, genome instability, tumor microenvironment modulation, enhanced cancer stemness, and metastasis.
  • Specific MUC1-mediated resistance mechanisms exist for chemotherapy, radiotherapy, and biotherapy.
  • MUC1's role in resistance varies across different cancer types.

Conclusions:

  • MUC1 is a critical factor in multifaceted tumor therapy resistance.
  • Understanding MUC1's mechanisms can guide the development of novel cancer treatments.
  • Further research and clinical trials targeting MUC1 are warranted.
Keywords:
BiotherapyCancer therapy resistanceChemotherapyMUC1Radiation therapy

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