Plasma advanced oxidation products as an additional tool in assessment of post-infarction heart failure

Area of Science:

• Cardiology
• Biochemistry
• Biomarkers

Background:

• Heart failure (HF) post-myocardial infarction is a significant clinical challenge.
• Oxidative stress plays a crucial role in the pathophysiology of post-infarction HF.
• Identifying reliable diagnostic tools for HF assessment is critical.

Purpose of the Study:

• To evaluate oxidative stress markers as potential diagnostic tools for post-infarction heart failure (HF).
• To determine the association between specific oxidative stress markers and HF severity, categorized by ejection fraction (EF).

Main Methods:

• Observational study involving 81 HF patients across EF subgroups (≥50%, 40-49%, <40%) and 68 healthy controls.
• Measurement of plasma advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances, catalase activity, and free thiols.
• Statistical analyses including logistic regression and receiver operating characteristic (ROC) curve analysis.

Main Results:

• Significant differences in oxidative stress markers were observed between HF patients and controls.
• AOPP levels were significantly higher in HF patients with EF <40%.
• AOPP showed a significant association with HF in the EF ≥50% group, with an identified cut-off value of 60.89 µmol/l.

Conclusions:

• Advanced oxidation protein products (AOPP) may serve as a valuable additional diagnostic tool for assessing post-infarction heart failure.
• The findings suggest AOPP is particularly relevant for HF assessment in patients with preserved ejection fraction (EF ≥50%).
• ROC curve analysis supports the utility of AOPP in HF diagnosis.