Related Experiment Video
Updated: Aug 16, 2025
05:28
Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
3.6K
ADAM10-a "multitasker" in sepsis: focus on its posttranslational target
Shuanglin Liao1, Yao Lin2, Lizhen Liu1
1The Intensive Care Unit, The First Dongguan Affiliated Hospital, Guangdong Medical University, Jiaoping Road 42, Tangxia Town, Dongguan, 523710, Guangdong, China.
Summary
A disintegrin and metalloproteinase 10 (ADAM10) is crucial in sepsis pathogenesis, regulating inflammation and vascular function. Understanding its substrates and mechanisms offers therapeutic targets for sepsis.
Area of Science:
- Biochemistry
- Immunology
- Pathophysiology
Background:
- Sepsis involves uncontrolled inflammation, leading to vascular barrier disruption and organ dysfunction.
- A disintegrin and metalloproteinase 10 (ADAM10) acts as a key regulator of proteolysis in sepsis.
- ADAM10 cleaves substrates like cytokines and cadherins, influencing intercellular communication and acting as a receptor for Staphylococcus aureus α-toxin.
Purpose of the Study:
- To review the multifaceted roles of ADAM10 in sepsis.
- To elucidate ADAM10's substrate-specific modulation and precise targets in sepsis.
- To highlight posttranslational mechanisms of ADAM10 for potential therapeutic intervention.
Main Methods:
- Computer-based online literature search.
- Utilized PubMed and Google Scholar databases.
- Focused on articles concerning ADAM10 and sepsis.
Main Results:
- ADAM10 plays a pivotal role in sepsis-induced inflammation and microcirculation dysfunction.
- Its enzymatic activity and diverse substrates impact endothelium-immune cell interactions.
- ADAM10's function is modulated by posttranslational mechanisms and subcellular localization.
Conclusions:
- ADAM10 is central to sepsis pathophysiology, affecting vascular integrity and immune responses.
- Further research into ADAM10's specific targets and regulation is needed.
- Targeting ADAM10 may offer novel therapeutic strategies for sepsis treatment.
Related Concept Videos
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.6K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.6K
01:22PI3K/mTOR/AKT Signaling Pathway
3.8K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.8K