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miRNAs as cornerstones in diabetic microvascular complications

Ahmed Ismail1, Hesham A El-Mahdy1, Mahmoud Gomaa Eldeib2

  • 1Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231, Cairo, Egypt.

Molecular Genetics and Metabolism
|December 24, 2022
PubMed

Insights

MicroRNAs (miRNAs) are key players in diabetic microvascular complications like nephropathy and retinopathy. Specific miRNAs, such as miR-146a, significantly impact these conditions by targeting vascular endothelial growth factors.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • Diabetic microvascular complications, including nephropathy, retinopathy, and neuropathy, are common.
  • MicroRNAs (miRNAs) are implicated in the pathogenesis of these complications by regulating key cellular pathways.

Purpose of the Study:

  • To review updated knowledge on the role of miRNAs in diabetic microvascular complications.
  • To summarize molecular pathways mediating hyperglycemia-induced vascular damage in type 2 diabetes mellitus (T2DM).

Main Methods:

  • Extensive literature search of PubMed Central for articles published after 2000.
  • Systematic collection and presentation of data on miRNA involvement in diabetic microvascular complications.

Main Results:

  • miR-126, miR-29b, and miR-125a are involved in diabetes-induced microvascular issues.
  • miR-146a is linked to all examined microvascular complications.
  • Vascular endothelial growth factors are the primary miRNA targets in these conditions.

Conclusions:

  • miRNAs play a critical role in the pathogenesis of diabetic microvascular complications.
  • Understanding miRNA roles offers insights into potential therapeutic targets for T2DM vascular complications.
Keywords:
Diabetic nephropathyDiabetic neuropathyDiabetic retinopathyMicrovascular complications

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