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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Related Experiment Video

Updated: Aug 16, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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[Three-dimensional Quantitative Evaluation Method in 123I-MIBG Myocardial SPECT-CT].

Yoshiaki Yasumoto1, Hiromitsu Daisaki2, Tadaki Nakahara3

  • 1Department of Radiology, Saitama City Hospital.

Nihon Hoshasen Gijutsu Gakkai Zasshi
|December 25, 2022
PubMed
Summary

This study introduces a method to evaluate myocardial standardized uptake value (SUV) using 123I-metaiodobenzylguanidine (MIBG) SPECT-CT imaging. The proposed method offers repeatable quantitative assessment of myocardial uptake, outperforming the traditional H/M ratio.

Keywords:
123I-metaiodobenzylguanidine (MIBG)heart-to-mediastinum ratio (H/M)quantificationsingle photon emission computed tomography-computed tomography (SPECT-CT)standardized uptakevalue (SUV)

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Area of Science:

  • Nuclear medicine
  • Medical imaging
  • Cardiology

Context:

  • Distinguishing neurodegenerative diseases requires accurate assessment of cardiac autonomic function.
  • 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a key imaging modality for evaluating cardiac sympathetic denervation.
  • Quantitative analysis of MIBG uptake in the myocardium can improve diagnostic accuracy.

Purpose:

  • To develop and validate a method for quantifying myocardial standardized uptake value (SUV) from SPECT-CT images.
  • To assess the accuracy and repeatability of the proposed myocardial SUV measurement.
  • To compare the quantitative performance of myocardial SUV with the conventional heart-to-mediastinal (H/M) ratio.

Summary:

  • Optimal reconstruction parameters (10 iterations, 10 subsets, 4-pixel FWHM Gaussian filter) were determined using a phantom study.
  • The proposed method demonstrated good repeatability for maximum SUVmax (MaxSUVmax) and average SUVmax (AveSUVmax) with %CVs of 4.99% and 4.84%, respectively.
  • Myocardial SUVs in normal cases (average MaxSUVmax=8.27, AveSUVmax=7.58) showed values closer to theoretical expectations than the H/M ratio.

Impact:

  • This quantitative method enables more accurate and repeatable assessment of myocardial MIBG uptake.
  • Improved quantification may enhance the ability to distinguish neurodegenerative diseases based on cardiac autonomic function.
  • The findings support the clinical utility of myocardial SUV as a superior quantitative metric compared to the H/M ratio.