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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy
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Lesion depth and marrow stimulation results.

Wael Abdalkarim Aldahshan1, Ashraf Mohammed Abdelaziz1, Faisal Ahmad Elsherief1

  • 1Faculty of Medicine for Girls, Al-Azhar University, 6th district Nasser City, Cairo, Egypt.

Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons
|December 25, 2022
PubMed
Summary

Osteochondral lesion depth significantly impacts marrow stimulation outcomes. Lesions less than 5 mm deep showed better results than those over 5 mm, highlighting depth as a key factor in treatment success.

Keywords:
DepthMarrow stimulationOsteochondral lesions of the talusPrognostic factors

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Area of Science:

  • Orthopedic surgery
  • Sports medicine
  • Regenerative medicine

Background:

  • Osteochondral lesions (OCLs) of the talus are common injuries.
  • Treatment outcomes for OCLs can vary significantly.
  • Marrow stimulation is a common surgical technique for OCLs.

Purpose of the Study:

  • To evaluate the impact of osteochondral lesion depth on treatment outcomes after marrow stimulation.
  • To determine if OCL depth is an independent prognostic factor for clinical success.

Main Methods:

  • Prospective cohort study of 55 patients with talar OCLs.
  • Patients divided into two groups based on lesion depth: ≤5 mm and >5 mm.
  • Follow-up averaged 30 months, assessing clinical outcomes using Foot and Ankle Outcome Scores (FAOS).

Main Results:

  • Both groups showed significant improvement in FAOS (P < 0.001).
  • Group A (≤5 mm depth) achieved higher final FAOS (90 ± 4.3) compared to Group B (>5 mm depth) (75 ± 6.4).
  • Time to full weight-bearing was shorter for shallower lesions (12 weeks vs. 16 weeks).

Conclusions:

  • Osteochondral lesion depth is an independent factor influencing outcomes of arthroscopic marrow stimulation.
  • Lesions <5 mm deep generally have superior clinical outcomes compared to those >5 mm deep.
  • OCL depth is an important prognostic indicator for arthroscopic marrow stimulation of the talus.