Vascular responsiveness of isolated and perfused simian metacarpal veins to several vasoconstrictor substances

Using the cannula inserting method, vascular responses to 7 vasoconstrictor substances were investigated on isolated, perfused simian metacarpal veins. The vein was markedly constricted by an intraluminal administration of norepinephrine, phenylephrine and 5-hydroxytryptamine with a maximal increase in perfusion pressure of over 100 mmHg. Clonidine and xylazine induced only a slight vasoconstriction, but tyramine produced no significant constriction. A large dose of KCl induced a strong vasoconstriction. In this study, it was demonstrated that the simian metacarpal vein has a specific characteristic of vascular reactivity.