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Published on: January 7, 2015
Development of phimosis as an adverse drug reaction to capecitabine with irinotecan
Priyeshkumar Patel1, Nagendra Nath Mishra1, Taral Patel2
1Consultant Urologist, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, India.
Abstract:
We present a case of a 32-year-old male who developed capecitabine-induced phimosis which resolved spontaneously without the need for circumcision within a few days of discontinuation of chemotherapy. The patient was on capecitabine with irinotecan chemotherapy for peritoneal metastasis from adenocarcinoma of the lower esophagus. A detailed literature review showed a few case reports with penile and scrotal erythema, ulceration, and swelling along with hand-foot syndrome, but none reported the occurrence of phimosis with spontaneous resolution.
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