Histone modification of endothelial-mesenchymal transition in cardiovascular diseases

Area of Science:

• Cardiovascular Biology
• Epigenetics
• Cellular Differentiation

Background:

• Atherosclerosis (AS) pathogenesis involves endothelial-mesenchymal transition (EndMT), where endothelial cells gain mesenchymal traits, contributing to plaque development.
• Effective treatments for AS remain limited, highlighting the need to elucidate its underlying molecular mechanisms.
• EndMT is implicated in various cardiovascular conditions, but the precise molecular drivers are not fully understood.

Approach:

• This review synthesizes current research on the role of histone modifications in EndMT within the context of cardiovascular disease.
• Specific histone modifications discussed include methylation, demethylation, acetylation, and deacetylation.
• The review aims to identify potential therapeutic targets by focusing on histone-modifying enzymes.

Key Points:

• Histone modifications critically influence the EndMT process, impacting cardiovascular health.
• Understanding these epigenetic changes provides insights into the progression of atherosclerosis.
• Targeting enzymes responsible for histone modifications presents a promising avenue for novel cardiovascular therapies.

Conclusions:

• Epigenetic regulation via histone modifications plays a significant role in EndMT and cardiovascular disease.
• Further research into histone-modifying enzymes could lead to targeted therapeutic interventions for atherosclerosis and related conditions.
• This review underscores the importance of exploring epigenetic mechanisms for advancing cardiovascular disease treatment.