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Outer membrane vesicles from bacteria: Role and potential value in the pathogenesis of chronic respiratory diseases

Fei Han1, Weiwei Wang2, Meng Shi3

  • 1Department of Laboratory Medicine, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Frontiers in Cellular and Infection Microbiology
|December 26, 2022
PubMed

Insights

Bacterial outer membrane vesicles contribute to pneumonia by delivering harmful molecules to host cells. Targeting these vesicles offers a promising new strategy for treating respiratory infections.

Area of Science:

  • Microbiology
  • Immunology
  • Pathophysiology

Background:

  • Infectious diseases, particularly respiratory infections, are a major global cause of mortality.
  • Bacterial extracellular membrane vesicles are increasingly recognized as key virulence factors.
  • These vesicles deliver various biomolecules, influencing host cell function during infection.

Purpose of the Study:

  • To review the current understanding of bacterial membrane vesicles in pneumonia.
  • To explore their role in the pathophysiology of pneumonia and its complications.
  • To highlight their potential as therapeutic and preventive targets.

Main Methods:

  • Literature review of current research on bacterial membrane vesicles.
  • Analysis of studies investigating vesicle composition and function.
  • Synthesis of information on vesicle involvement in pneumonia pathogenesis.

Main Results:

  • Bacterial membrane vesicles mediate pathogenicity by delivering nucleic acids, proteins, lipids, and carbohydrates to host cells.
  • These vesicles play a significant role in the development and progression of pneumonia.
  • Evidence supports their involvement in the complications associated with pneumonia.

Conclusions:

  • Bacterial membrane vesicles are critical effectors in pneumonia pathogenesis.
  • They represent a novel and promising target for developing future therapies and preventative strategies against respiratory infections.
Keywords:
bacteriaextracellular vesiclesmechanisms of diseaseouter membrane vesiclesrespiratory tract diseases

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