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Localization and potential role of prostate microbiota
Koichi Okada1, Kentaro Takezawa1, Go Tsujimura1
1Department of Urology, Osaka University of Graduate School of Medicine, Suita, Japan.
Frontiers in Cellular and Infection Microbiology
|December 26, 2022
Summary
The prostate microbiota resides in the prostatic duct. Reduced microbial diversity in the prostate is linked to benign prostate enlargement (BPE), suggesting a role in the condition.
Area of Science:
- Microbiology
- Urology
- Genitourinary System Research
Background:
- The prostate gland's microbial community composition and its role in benign prostate enlargement (BPE) remain incompletely understood.
- Previous studies have not definitively established the presence and specific location of prostate microbiota, nor its relationship with BPE.
Purpose of the Study:
- To determine the presence and localization of the prostate microbiota.
- To investigate the association between prostate microbiota and benign prostate enlargement (BPE).
Main Methods:
- 16S metagenomic analysis of prostate tissues and catheterized urine from 15 patients.
- Fluorescence in situ hybridization (FISH) and in situ hybridization (ISH) for bacterial localization.
- Comparison of prostate microbiota diversity and composition between BPE and non-BPE groups.
Main Results:
- Prostate tissue exhibited significantly higher microbial diversity (Faith's phylogenetic diversity index) compared to urine.
- Distinct microbial communities were observed between prostate tissue and urine.
- Bacteria were localized within the prostatic duct.
- Reduced microbial diversity (Chao1 index) and increased abundance of Burkholderia were found in the BPE group compared to the non-BPE group.
Conclusions:
- The prostate microbiota is confirmed to be present and localized within the prostatic duct.
- A reduction in prostate microbial diversity is associated with benign prostate enlargement.
- These findings suggest a potential role for prostate microbiota in the pathogenesis of BPE.
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