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Correlation between COVID-19 and hepatitis B: A systematic review.
Yan-Fei He1, Zhi-Gang Jiang2, Ni Wu3
1Health Management Center, The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China. heyanfeilc@163.com.
World Journal of Gastroenterology
|December 26, 2022
Summary
This review explores the connection between coronavirus disease 2019 (COVID-19) and hepatitis B virus (HBV) infection. While some studies suggest an association, further research is needed to clarify the interaction between these two significant health concerns.
Area of Science:
- Hepatology and Virology
- Infectious Diseases
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) frequently presents with liver impairment.
- Hepatitis B virus (HBV) remains a significant global health issue.
- The interplay between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and HBV regarding liver damage and disease progression is not fully understood.
Approach:
- A comprehensive literature search was conducted across major databases (PubMed, Scopus, Web of Science, etc.) from December 2019 to September 2022.
- Included were 57 studies with human data on hepatitis B and COVID-19, encompassing case reports and quantitative findings.
- Gray literature and references were also reviewed to ensure a thorough analysis.
Key Points:
- Of 57 eligible studies, 42 reported liver enzyme abnormalities in COVID-19 patients with hepatitis B.
- Most studies suggested an interaction between hepatitis B and COVID-19, with 6 reporting HBV activation.
- Twelve studies found no significant interaction, highlighting the complexity of the relationship.
Conclusions:
- A potential association exists between COVID-19 and hepatitis B.
- High-quality randomized controlled trials are necessary to definitively establish the interaction between COVID-19 and hepatitis B.
