[Depression of fibrinolysis in long-term stress in the rat]

A study of fibrinolytic and hemostatic effects of emotional/painful stress induced by Dosiderato's technique in white Wistar rats demonstrated, 4 hours after discontinuation of 6-hour stress exposure, a thrombophilic condition that is characterized by heavily depressed fibrinolysis in combination with increased blood antiplasmin and coagulation activities. It is suggested that depressed fibrinolysis is a result of depletion of fibrinolytic elements, plasminogen activator in particular.