Cytomegalovirus and Hemolytic Anemia in an Immunocompetent Adult

Hemolytic anemia is an increasingly recognized complication of cytomegalovirus (CMV) infection in immunocompetent patients. Although it is thought to be immune-mediated, other mechanisms have been proposed. The decision to treat is controversial but it may include antiviral and immunosuppressive therapy. We report a case of CMV-induced hemolytic anemia in a previously healthy 55-year-old woman. The patient presented with asthenia and choluria, and laboratory tests showed severe anemia with hyperbilirubinemia and elevated lactate dehydrogenase. A diagnosis of hemolytic anemia was made. Structural, enzymatic, toxic, pharmacological, and neoplastic causes were excluded. The CMV immunoglobulin M was positive, with a negative direct antiglobulin test. The patient had an improvement in clinical and laboratory status without any treatment, and two months later she had a full recovery of the anemia. This case illustrates that CMV infection might be associated with severe organ damage in immunocompetent patients but has an overall good prognosis without any directed treatment.