Facile Synthesis of TiO₂-SiO₂-P₂O₅/CaO/ZnO with a Core-Shell Structure for Bone Implantation

A facile synthesis method was developed to synthesize TiO₂-SiO₂-P₂O₅/CaO or TiO₂-SiO₂-P₂O₅/ZnO with a core-shell structure. The carboxylic cation exchanger Tokem-250 has a high selectivity for Ca²⁺/Zn²⁺ ions and was used in this study. The framework of the material in the shell was TiO₂-SiO₂-P₂O₅, and the inner part was filled with CaO (sample TiO₂-SiO₂/CaO) or ZnO (sample TiO₂-SiO₂-P₂O₅/ZnO). A stepwise heat treatment (drying in a drying oven at 60 °C for 30 min, then annealing in a muffle furnace for 30 min at 150, 250, and 350 °C, at 600 °C for 6 h, and at 800 °C for 1 h) was needed to obtain a homogeneous material. The poly(vinyl alcohol) was used as a binding additive. The obtained composites were characterized by a regular structure and highly developed surface. The samples exhibit bioactive properties in the simulated body fluid (SBF) solution, since the surface contains active centers (Si⁴⁺, Ti⁴⁺) which contribute to mineralization and precipitation of the calcium-phosphate compounds on the surface from biological media. The TiO₂-SiO₂-P₂O₅/CaO-PVA samples did not exceed acceptable hemolysis levels for medical materials.